An investigation of NOS2A promoter polymorphisms in Australian multiple sclerosis patients
نویسندگان
چکیده
منابع مشابه
Investigation of an inducible nitric oxide synthase gene (NOS2A) polymorphism in a multiple sclerosis population.
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) affecting most commonly the Caucasian population. Nitric oxide (NO) is a biological signaling and effector molecule and is especially important during inflammation. Inducible nitric oxide synthase (iNOS) is one of the three enzymes responsible for generating NO. It has been reported that there is an ex...
متن کاملAN INVESTIGATION OF HUMAN APOLIPOPROTEIN E POLYMORPIDSMS IN MULTIPLE SCLEROSIS PATIENTS OF IRAN
Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system, with a complex etiology that includes a strong genetic component. The chromosome 19q 13 region surrounding the apolipoprotein E (APOE) gene has shown consistent evidence of involvement in MS. In a cross-sectional study, to show the APOE genotype and allele frequency in the MS population of Iran in comp...
متن کاملMolecular Analysis of rs2070744 and rs1799983 Polymorphisms of NOS3 Gene in Iranian Patients With Multiple Sclerosis
Introduction: Multiple Sclerosis (MS) is a disease of central nervous system that mainly causes lesions or plaques in the spinal cord and brain. The purpose of this study was to analyze the relation between c.-813C>T (rs2070744) and c.894G>T (rs1799983) polymorphisms of NOS3 gene and MS in Iranian patients. Methods: A total of 78 patients with MS and 80 healthy controls were screened for NOS3 ...
متن کاملInvestigation of genetic variation of IL-4 receptor rs1801275 in patients with multiple sclerosis in Isfahan
Aim and Background: Multiple sclerosis (MS) is an autoimmune inflammatory disease that attacks myelinated axons in the central nervous system (CNS) resulting in destroying the myelin and the axon. According to high prevalence of disease in Iran, it needs to study different aspects of disease including factors influencing the pathogenesis and the other risk factors. Various type of genetic varia...
متن کاملil-7r α polymorphisms in 60 iranian multiple sclerosis patients.
background: multiple sclerosis (ms), a chronic inflammatory demyelinating disorder with neurodegenerative aspects, is more common among young adults, particularly women. methods: this molecular study was designed to investigate the il-7r α chain gene in iranian ms patients. we studied 60 ms patients, diagnosed based on 2005 r-mcdonald criteria and 60 apparently healthy individuals as the contro...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: European Journal of Human Genetics
سال: 2005
ISSN: 1018-4813,1476-5438
DOI: 10.1038/sj.ejhg.5201422